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KMID : 0545120090190060616
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 6 p.616 ~ p.621
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Glycosaminoglycan Degradation-Inhibitory Lactic Acid Bacteria Ameliorate 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice
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Lee Bo-Mi
Lee Jung-Hee
Lee Hye-Sung
Bae Eun-Ah
Huh Chul-Sung
Ahn Young-Tae
Kim Dong-Hyun
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Abstract
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To evaluate the effects of lactic acid bacteria (LAB) in inflammatory bowel diseases (IBD), we measured the inhibitory effect of several LAB isolated from intestinal microflora and commercial probiotics against the glycosaminoglycan (GAG) degradation by intestinal bacteria. Bifidobacterium longum HY130101 and Lactobacillus plantarum AK8-4 exhibited the most potent inhibition. These LAB inhibited colon shortening and myeloperoxidase production in 2,4,6- trinitrobenzenesulfonic acid (TNBS)-induced experimental colitic mice. These LAB also blocked the expression of the proinflammatory cytokines, IL-1β and TNF-α, as well as of COX-2, in the colon. LAB also blocked activation of the transcription factor, NF-κB, and expression of TLR-4 induced by TNBS. In addition, LAB reduced the TNBS-induced bacterial degradation activities of chondroitin sulfate and hyaluronic acid. These findings suggest that GAG degradation-inhibitory LAB may improve coltis by inhibiting inflammatory cytokine expresion via TLR-4-linked NF-kB activation and by inhibiting intestinal bacterial GAG degradation.
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KEYWORD
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Lactic acid bacteria, inflammatory bowel disease, glycosaminoglycan, TLR-4, intestinal bacteria
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